Go to Configuration → Game Types, create several game types and set the required number of players in the hand and table size in each type:
Statistics for each game type will be counted separately.
Note that you can also divide game types by other parameters. Don’t forget to select HUD and popup profile you want to use in each type of game.
After changing game types settings, you need to rebuild the statistics for the changes to take effect for the entire database. Click “Clear stats“, then “Build stats” in the main Hand2Note window.